ScienceDaily posted a very fascinating article about the connection between skin-gut communication!
Here are the fast facts:
- The study led was led by researchers in Boston Children’s Hospital
- Researchers used small strips of tape on mice, that they would later remove to collect data
- The purpose of the tape was to produce a cell-signaling protein called IL-33 to enter the bloodstream
- IL-33 and IL-25 (found in the intestine lining) are two proteins that worked together inside the gut
- Together they activated ILC2’s (2 innate lymphoid cells)
- This triggered two additional cell-signaling proteins IL-13 + IL-4 – they are responsible for expanding intestinal mast cells
- EXPANSION OF MAST CELLS MAKES IT EASIER FOR ALLERGEN TO ENTER THE TISSUE!
- The mice with the strip tape had more severe reactions to food allergens than mice that did not
- Additional work is still being done.