Scratching the skin primes the gut for allergic reactions to food

ScienceDaily posted a very fascinating article about the connection between skin-gut communication!

Here are the fast facts:

  • The study led was led by researchers in Boston Children’s Hospital
  • Researchers used small strips of tape on mice, that they would later remove to collect data
  • The purpose of the tape was to produce a cell-signaling protein called IL-33 to enter the bloodstream
  • IL-33 and IL-25 (found in the intestine lining) are two proteins that worked together inside the gut
  • Together they activated ILC2’s (2 innate lymphoid cells)
  • This triggered two additional cell-signaling proteins IL-13 + IL-4 – they are responsible for expanding intestinal mast cells
  • EXPANSION OF MAST CELLS MAKES IT EASIER FOR ALLERGEN TO ENTER THE TISSUE!
  • The mice with the strip tape had more severe reactions to food allergens than mice that did not
  • Additional work is still being done.

Source: https://www.sciencedaily.com/releases/2019/04/190423133803.htm

Leave a Reply

Your email address will not be published.